NLRP3 plays a crucial role in the development of PIH and PE, leading to the occurrence of hypertension, through sympathetic outflow and RAAS activation, to proteinuria, through tubulointerstitial inflammation and glomerulopathy, to placental abruption, through immunothrombosis, and to the development of HELLP syndrome, through immunothrobosis, cytokine-mediated hemolysis, and the induction of hepatocyte apoptosis and pyroptosis. This evidence concerns the gene NLRP3 and HELLP syndrome.