Considering the aforementioned data induction of NLRP3 i.e., by high concentrations of NaCl, induces inflammation in the paraventricular nucleus of the hypothalamus, leading to sympathetic outflow, which results in the activation of RAAS, and angiotensin II leads to further induction of inflammation and NLRP3 activation, which closes the cycle of hypertension pathomechanism. Here, NLRP3 is linked to hypertensive disorder.