In order to confirm that hypothesis and delineate the role of NLRP3 in the development of hypertension in preeclampsia, Shirasuna et al. induced PE in pregnant wild type mice, NLRP3 knock-out mice (NLRP3 −/−), and ASC knock-out mice (asc −/−) [15]. This evidence concerns the gene NLRP3 and hypertensive disorder.