However, in both NLRP3 −/− and asc −/− groups SBP was significantly lower in comparison to the wild type group, and this effect was considerably more pronounced among NLRP3 knock-out mice than ASC knock-out mice, indicating the substantial role of NLRP3 inflammasome in the development of hypertension in preeclampsia [15]. The gene discussed is PYCARD; the disease is hypertensive disorder.