Omi et al. examined 1911 patients (987 with hypertension, 924 controls), discovering that homozygotes of high activity NLRP3 alleles, whose NLRP3 inflammasomes produce more chemokines after stimulation, had a greater risk of hypertension development compared to both heterozygotes and homozygotes of low activity NLRP3 alleles (odds ratio 1.24, p = 0.03) [10]. Here, NLRP3 is linked to Hypertension.