Additionally, CRNDE indirectly inhibits post-transcriptional expression of B-cell lymphoma 2 (Bcl-2) and wingless-type MMTV integration site family, member 2 (Wnt2), which are two downstream effectors of the PI3K/AKT/mTOR signaling pathway that are involved in the malignant characteristics of gliomas, through complete binding to miR-136-5p [97]. The gene discussed is WNT2; the disease is central nervous system cancer.