CD4 and COVID-19: Moreover, the number of immunosuppressive T-regulatory, T-reg (CD4+CD25+Foxp3+) cells and concentrations of IL-6, IL-10, and C-reactive protein (CRP) were up-regulated in patients with severe COVID-19 [18], suggesting that SARS-CoV-2 infection may lead to “over-immunosuppression” in the case of obesity (Figure 1).