ASIC2 and central nervous system cancer: Analysis of the TCGA GBM database (TCGA GBM and GTEX studies via Xena platform) revealed that the ASIC1 mRNA expression is up-regulated in tissue samples of patients with glioma compared to healthy people, while ASIC2 and ASIC3 gene expression is down-regulated [13], consistent with our data obtained on primary GBM cells (Figure 8a).