NLRP3 and cardiovascular disorder: Since inflammation is associated with atherosclerosis progression and the secretion of IL-1β is a critical factor for its pathogenesis [76,77], the use of the polyphenol thonningianin A (TA) extracted form P. chinense was tested in a mouse model of cardiovascular disease, showing a decrease in the NLRP3 and IL-1β expression [51].