Resaerchers have reported that luteoloside suppresses hepatocellular carcinoma cells (HCC) through the inhibition of HCC migration and invasion and has the capacity to downregulate the expression level of NLRP3, caspase-1 and IL-1β, suppressing proliferation and metastasis of HCC [132]. The gene discussed is IL1B; the disease is hepatocellular carcinoma.