Piperine is an alkaloid phenolic compound, which is the main bioactive component of pepper, and Cepharanthine is a natural alkaloid extracted from the plant Stephanie cepharantha “hayata”. Abderrazak et al. [96] administered these two compounds in a rat model of diabetes and the results of the compounds and their combination showed a decrease in the mRNA and protein levels of TXNIP and NLRP3 in renal tissues. Here, NLRP3 is linked to diabetes mellitus.