Many factors may affect the severity of allergic reaction, such as region of residency, type of exposure (natural, occupational or iatrogenic), IgE specific activity (sIgE/T-IgE), etc. Since IgE specific activities are directly related to severity of allergic reactions in venom allergy patients, unlike the low predictive value of Venom-specific IgE (sIgE) in assessment of severity, Guan et al. claim that sIgE/T-IgE may provide more accurate information for diagnosis than serum sIgE [22]. The gene discussed is IGHE; the disease is allergic disease.