ICAM1 and Hypoglycemia: In agreement with this idea, PMNs could also be activated by glucose homeostasis variation, such as acute hyper-and hypoglycemia, and these variations can concur, generating advanced glycosylation-end products (AGEs) that promote cellular dysfunction and endothelial expression of several adhesion molecules, such as vascular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and selectins [15,16,17].