Lack of macrophage response to IL-10 results in the expression of several pro-inflammatory mediators and the development of colitis in mice: in particular, IL-23 secretion by IL-10Rα-negative macrophages induces IL-22 release by ILC3 and Th17 T cells, leading to the occurrence of colitis [22,29]. The gene discussed is IL10RA; the disease is colitis.