CCR5 and neoplasm: Recently, it has been reported that the pharmaceutical inhibition of CCR5 induces an anti-tumoral repolarization of TAMs in metastatic CRC: of note, CCR5 blockade induces a STAT3/SOC3-mediated phenotype switch in TAMs, together with a reduction of CD163+ cells and a reshape of myeloid cell composition in the tumor microenvironment.