GCKR and metabolic dysfunction-associated steatotic liver disease: The susceptibility to developing NAFLD comprises inherited risk factors, as described earlier, such as I148M PNPLA3, E167K TM6SF2, P446L GCKR, and rs641738 in MBOAT7. As these variants are nutrient-sensing, nutritional genomics approaches can be utilized in the future as interventions that make use of beneficial nutrients suitable to the patients’ genomes and avoid those that have unhealthy effects.