The susceptibility to developing NAFLD comprises inherited risk factors, as described earlier, such as I148M PNPLA3, E167K TM6SF2, P446L GCKR, and rs641738 in MBOAT7. As these variants are nutrient-sensing, nutritional genomics approaches can be utilized in the future as interventions that make use of beneficial nutrients suitable to the patients’ genomes and avoid those that have unhealthy effects. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.