Several late-stage clinical trials are also investigating the effects of agents that target the mechanisms involved in advanced stages of NAFLD, such as inflammation (C-C chemokine receptor CCR2/CCR5 antagonist cenicriviroc), apoptosis (caspase inhibitor emricasan, apoptosis signal-regulating kinase 1 ASK1 inhibitor selonsertib), and fibrosis (galectin-3 inhibitor belapectin). This evidence concerns the gene MAP3K5 and metabolic dysfunction-associated steatotic liver disease.