As NAFLD is characterized by a disturbance in lipid and glucose homeostasis, drugs targeting de novo lipogenesis and glucose metabolism, such as stearoyl-CoA desaturase 1 (SCD1) and acetyl CoA carboxylase (ACC) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and fibroblast growth factor (FGF) analogues, are currently being tested in phase 2 or 3 clinical trials. Here, SLC5A2 is linked to metabolic dysfunction-associated steatotic liver disease.