Within the nuclear receptor superfamily, PPARs, farnesoid X receptor (FXR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), LXR, and thyroid hormone receptor-β (THR-β) are key regulators of the gut-liver-adipose tissue axis and control the expression of genes involved in lipid and glucose metabolism, bile acid homeostasis, and inflammation, which are all features of NAFLD/NASH [214,215,216]. The gene discussed is NR1I3; the disease is metabolic dysfunction-associated steatohepatitis.