Additional Sex Combs Like 1 (ASXL1), a protein frequently affected by mutations in myeloid malignancies, has been shown to physically interact with EZH2 and influence PRC2 recruitment in hematopoietic cells, thus regulating gene expression by facilitating PRC2-mediated transcriptional repression of known leukemic oncogenes [10] (Figure 1). This evidence concerns the gene EZH2 and myeloid neoplasm.