KDR and glioblastoma: Our previous work showed that MBZ′s anti-tumor effect in glioblastomas and medulloblastomas is caused by multiple different mechanisms, such as the inhibition of microtubule formation and VEGFR2 autophosphorylation [17,18], which was corroborated by other investigators, applied to various preclinical cancer models and ultimately translated into clinical trials for adult and pediatric patients with cancer (NCT03925662, NCT03628079, NCT02644291, NCT01729260, NCT01837862).