Although the TLR4 Asp299Gly polymorphism has been associated with reduced CIMT and lower serum levels of inflammatory cytokines in healthy populations, and reduced risk of myocardial infarction in Caucasians [16, 24, 25], to date, these studies have provided diverse results on the role of the TLR4 polymorphisms in the development of atherosclerosis [16, 24–30]. The gene discussed is TLR4; the disease is myocardial infarction.