In the present study we show that CBR-470-1 activates the Nrf2 cascade in SH-SY5Y neuroblastoma cells, causing disassociation of the Keap1-Nrf2 complex, cytosol Nrf2 protein stabilization and nuclear translocation, followed by increased expression of Nrf2 pathway genes (HMOX1, NQO1 and SOD1). The gene discussed is SOD1; the disease is neuroblastoma.