Furthermore, the concentration of apoE in HDL containing or lacking apoJ was differentially associated with ADAS-cog scores (difference in ADAS-cog score per 1-SD higher apoE in HDL that contains apoJ, 0.05 [95% CI, −0.06 to −0.16]; difference in ADAS-cog score per 1-SD higher apoE in HDL that lacks apoJ, −0.24 [95% CI, −0.36 to −0.12]; P for heterogeneity = .005) but not with dementia (Table 4). This evidence concerns the gene APOE and dementia.