APOC3 and dementia: To evaluate associations of apolipoprotein E protein levels in different lipoproteins with cognitive function and risk of dementia, this case-cohort study embedded in the Ginkgo Evaluation of Memory Study analyzed data from 1351 community-dwelling participants 74 years and older, and found the presence of apoE in high-density lipoproteins that lack apolipoprotein C3 was associated with better cognitive function and decreased risk of dementia.