Synthetic lethal partnerships of PNKP with PTEN in colon cancer cell lines, and with the protein tyrosine phosphatase SHP-1 in T-cell lymphoma cell line have been identified, and where the combination of deficiencies in these proteins with A12B4C3 is effective in cell killing [53,54]. This evidence concerns the gene PTEN and T-cell non-Hodgkin lymphoma.