The enhanced RBM3 expression is still maintained 4‐5 weeks after HT; meanwhile, the cognitive deficits, loss of spines and tau phosphorylation at part sites are efficaciously reversed in TBI + HT group compared with TBI group, suggesting that the enhanced RBM3 induced by cooling parallels with reduction in TBI‐induced brain injuries. This evidence concerns the gene RBM3 and Cognitive impairment.