Therefore, we speculated that RBM3 overexpression by AAV mediation should mimic neuroprotective role of cooling stress in TBI‐associated AD mouse models, if enhanced RBM3 expression induced by hypothermia mediates protecting against memory and LTP deficits, loss of spine and tau phosphorylation in TBI‐associated AD mouse models. This evidence concerns the gene RBM3 and Alzheimer disease.