In this study, we found that hypothermia pre‐treatment could induce expression of RBM3, meanwhile the TBI‐induced spatial learning and memory deficits and the loss of spines, LTP inhibition and AD‐like tau phosphorylation are also reversed completely or partly, as well as that the protective effect of hypothermia pre‐treatment on the brain of TBI mice is abolished when blocking expression of RBM3. The gene discussed is RBM3; the disease is Alzheimer disease.