Accordingly, the results show that in broad cancer types (ACC, BLCA, BRCA, COAD, KICH, KIRC, KIRP, LGG, LIHC, LUSC, PAAD, PRAD, PEAD, STAD and THCA), YIF1B expression significantly and highly correlates with expression of MMR genes; MLH1, MSH2 and MSH6 all positively correlated with YIF1B in most of these cancer types. This evidence concerns the gene MSH2 and cancer.