SS-31 treatment offers cardioprotection in models of cardiac ischemia-reperfusion and myocardial infarction (Cho et al., 2007a; Brown et al., 2014; Dai et al., 2014c; Kloner et al., 2012; Shi et al., 2015; Szeto, 2008), it also prevents cardiac fibrosis and hypertrophy induced by 4-week Angiotensin II infusion (Dai et al., 2011b). This evidence concerns the gene AGT and ischemia.