To explore whether the relative abundance of cancer cells in the tumor might affect labeling, we infused mice with pancreatic tumors derived from orthotopic injection of a syngeneic KrasG12D; Trp53-/- pancreatic cancer cell line derived from tumors arising in the KP-/-C model (Danai et al., 2018), since cell line transplantation models are thought to result in tumors with a less dense, desmoplastic stroma compared to autochthonous models (Baker et al., 2016; Olive et al., 2009). Here, TP53 is linked to familial pancreatic carcinoma.