IGHE and anaphylaxis: Immunoglobulin-E (IgE)-mediated reactions due to CM intake may present as cutaneous reactions (e.g., urticaria, angioedema, and atopic dermatitis), respiratory reactions (asthma and rhinitis), gastrointestinal reactions (e.g., oral allergy syndrome and vomiting), or systemic reactions (anaphylaxis) (8).