Riquelme et al. also confirmed that not all oncogenic K-Ras mutants activate and enhance MAPK signaling by showing that the level of phospho-MEK1/2 is increased in NSCLC cells harboring the KRAS G12C and KRAS G12D mutations but decreased in cells harboring the KRAS G12R and G12S [3]. Here, KRAS is linked to non-small cell lung carcinoma.