Furthermore, sphere-formation assays revealed that UCA1 was also responsible for stemness maintenance by affecting the expression levels of the stem cell markers CD133, OCT4, Nanog, and SOX2 in human pancreatic ductal adenocarcinoma cell cultures [125], suggesting a UCA1/K-Ras/cancer stemness relationship. This evidence concerns the gene KRAS and pancreatic ductal adenocarcinoma.