In SDM rats, although their blood glucose was also high, as glucocorticoids can promote liver gluconeogenesis, the rate-limiting enzyme phosphoenolpyruvate carboxy-kinase and glucose-6-phosphatase activity increased, leading to increased liver glucose output [41, 42], and a liver 18F-FDG uptake lower than in T2DM rats. Here, G6PC1 is linked to type 2 diabetes mellitus.