Each of EGF, eotaxin, GRO-α, TGF-α, IL-1RA, TNF-α, IL-6, IL-8, IP-10, and IFN-γ, were significantly different for at least one MPN subtype (Supplemental Fig. 1B) or associated with decreased overall survival (IL-6, p = 0.01). The gene discussed is CXCL8; the disease is myeloproliferative neoplasm.