MYC and central nervous system cancer: In our gene-edited cells, these trends of global reduction of H3K27me3, some increases in H3K27ac, and elevated MYC family genes in H3.3 mutant cells are mostly consistent with trends previously observed when comparing H3.3K27M-mutated gliomas to H3.3WT cells6,9,22,23 but suggest K27M and G34R mutations may be functionally more similar than previously realized.