FHIT and cancer: The genomic identification of significant targets in cancer analyses (GISTIC) led to identify recurrent focal deletions (3p14.2 (FHIT), 11q11, and 4q13.2) and focal amplifications (17q13 (ERBB2), 8q24.21 (MYC), 3q26.31 (PIK3CA, TRAIL), 8q24.22, 8q21.13) (Fig. 3d and Supplementary Data 9).