The genomic identification of significant targets in cancer analyses (GISTIC) led to identify recurrent focal deletions (3p14.2 (FHIT), 11q11, and 4q13.2) and focal amplifications (17q13 (ERBB2), 8q24.21 (MYC), 3q26.31 (PIK3CA, TRAIL), 8q24.22, 8q21.13) (Fig. 3d and Supplementary Data 9). The gene discussed is PIK3CA; the disease is cancer.