TLR8 and tuberculosis: This picture was even more pronounced for 2-month signatures (the signature combining patient characteristics and transcriptional biomarkers included BCL2, CXCL10, IL13, STAT2, TLR6 and TLR8 combined with age, gender, BMI, cough ≥2 weeks, tobacco, alcohol, previously diagnosed TB, and severe thinness) and AUC values were also in general slightly higher, indicating higher predictive capability (Fig. 2b).