TLR8 and tuberculosis: However, the signature combining patient characteristics and transcriptional biomarker (AIRE, B2M, CD19, CXCL10, CXCL13, NCAM1, NLRC4, NLRP1, NLRP2, NOD2, TLR6 and TLR8 combined with gender, tobacco, alcohol, previously TB diagnosed and severe thinness) data led to an improved prediction corresponding to an AUC value of 0.89 (Fig. 2a).