In addition to the pathways described above, many other significant pathways showed similar Z-scores indicating inhibited action, including Neuroinflammation Signaling Pathway (p = 5.87E−04; activated Z-score: − 0.577), Calcium Signaling (p = 3.89E−03; Z-score: − 1.5), Synaptic Long Term Depression (p = 5.63E−03; Z-score: − 1.886), Glutamate Receptor Signaling (p = 1.58E−03; Z-score: − 0.447), Opioid Signaling Pathway (p = 9.86E−03; Z-score: − 0.853), and NF-κB Signaling (p = 2.93E−02; Z-score: − 1.5). This evidence concerns the gene NFKB1 and major depressive disorder.