APP and Dravet syndrome: As increased levels of soluble Aβ were observed already in foetal brains in DS [17], we examined cerebral organoids grown from induced pluripotent stem cells (iPSC) generated by non-integrational reprogramming of primary cells donated by people with DS, including an isogenic DS (T21) iPSC model [18], as a platform to analyse the T21-specific effects on APP proteolytic processing.