BACE1 and dementia: On the other hand, SNPs at the BACE2 locus (and not BACE1) correlate with the age of onset of dementia in people with DS [26], as well as sporadic LOAD in euploid people in the Finnish population [35], and a recent report showed that a de novo intronic deletion within one allele of BACE2 caused EOAD in a 50-year-old euploid person [36].