SFRP1 and posterior cortical atrophy: Evidence for a role of miR-744 in PCa progression has also been reported in studies where similar to miR-182, miR-744 was shown to activate the Wnt/β-catenin pathway by targeting multiple negative regulators of Wnt/β-catenin signalling, including SFRP1, GSK3β, TLE3 and NKD1.