EGR1 and posterior cortical atrophy: In this study, NGS analysis identified a putative signature of PCa holoclones, which depicted a pro-metastatic and pro-angiogenic phenotype mediated by the expression of multiple genes (e.g. SCF, EGR1, BCL6, IL-24 and LPCAT1), and miRNAs indicative of a pro-metastatic and invasive profile.