In turn, the most relevant genes to explain the GBM cluster were the CHI3L1, ANXA1, IGFBP3, COL1A2, COL1A1, NNMT, COL3A1, PDPN, POSTN, VEGFA, PTX3, TOP2A, HS3ST3B1, IGF2BP3, LOX, SHOX2, XIST and IBSP genes. The gene discussed is CHI3L1; the disease is glioblastoma.