In turn, the most relevant genes to explain the GBM cluster were the CHI3L1, ANXA1, IGFBP3, COL1A2, COL1A1, NNMT, COL3A1, PDPN, POSTN, VEGFA, PTX3, TOP2A, HS3ST3B1, IGF2BP3, LOX, SHOX2, XIST and IBSP genes. Here, IGFBP3 is linked to glioblastoma.