EMT is the key event underlying VM formation.31 E-cadherin, vimentin, N-cadherin, and snail were used as markers to reflect EMT during VM formation.32 We detected E-cadherin, N-cadherin, and snail expression in NSCLC cells pretreated with thrombin, r-hirudin, or DTIP. The gene discussed is SNAI1; the disease is non-small cell lung carcinoma.