To this end, we established an oral Salmonella infection model using an attenuated Salmonella-2W1S strain49, thus enabling tracking of the same endogenous 2W1S-specific CD4 T cell response within the draining secondary lymphoid tissue (mesenteric LNs (mLNs)) and the non-lymphoid effector site (colon). The gene discussed is CD4; the disease is Salmonella Infections.