Furthermore, recruiting an in vitro MDCK-MDR-GBM co-culture model, the EDT-IONPs could enhance DOX penetration through the MDCK-MDR1 monolayer over twofold and provided significantly higher anti-cancer effect than free DOX in GBM cells in the presence of an external magnetic field and ADTC5. Here, ABCB1 is linked to glioblastoma.