The proportions of sensitized patients against rAni s 7 and rAni s 1 in our allergic population were similar to those previously reported for patients with gastro-allergic anisakiasis or Anisakis-induced chronic urticaria17 and confirm previous reports on the immunodominant IgE response to these allergens (mainly to Ani s 7) during the infections by A. simplex28,34,37. This evidence concerns the gene IGHE and infection.