HORMAD1 and cancer: Together with the finding that releasing endogenous MCM8–MCM9 complex from HORMAD1 binding fully rescued the MLH1 chromatin binding and DNA mismatch repair defects in MDAH2774 cells, this observation strongly suggests that cytosolic retention of MCM8–MCM9 complex is the mechanism how HORMAD1 compromises DNA mismatch repair in cancer cells.