HORMAD1 and cancer: To test this possibility, we included all group I cancers that have distinct HORMAD1-positive populations (Fig. 1b) and examined if HORMAD1 expression was associated with features of genomic instability, including copy number alternation burdens (number of segments altered, number of local amplification/deletion, and fraction of genome altered) and loss of heterozygosity (LOH) burdens (number of segments with LOH and fraction of genome with LOH)24.