These processes should be investigated in parallel as we found evidence that inflammatory induced lysosomal dysfunction and intracellular lipid homeostasis seem to be tightly connected especially since a recent study demonstrated vATPases to be of crucial importance for ABCA1-mediated HDL efflux [70], a process known to be impaired in psoriasis patients as well.[12] Future therapeutic strategies could address lysosomal re-acidification as a mechanism by which to ultimately decrease CVD risk in chronically inflamed patients. This evidence concerns the gene ABCA1 and psoriasis.