TNF and psoriasis: Second, we found important effects of cytokines known to be active in psoriasis, specifically IFNγ and TNFα; a finding which was supported by a prior report of synergism of these cytokines in psoriasis skin and human atherosclerotic plaques.[32] Other reports have demonstrated various cellular mechanisms in various cell types modulated by these two cytokines.41, 42, 43, 44, 45