Mutations in 4 different SWI/SNF subunits including ARID1A/B were identified in three congenital syndromes that include both neural and cardiac defects: Coffin-Siris syndrome (CSS), Nicolaides-Baraitser syndrome (NCBRS), and ARID1B-related intellectual disability (ID) syndrome [13, 18–21]. This evidence concerns the gene ARID1A and intellectual disability-sparse hair-brachydactyly syndrome.