Conversely, the phenotype frequency of HLA-DRB1*04:05 was reported to be 0.7% in MS patients in Italy [37], and 0–5.3% in the European general population [40], but up to 25% in the Japanese general population and around 45% in Japanese MS patients [27, 29]. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.