The chance that the same residue sequences of ACE2 on the second chromosome also perfectly binds to the SARS-CoV-2 RBM is low, allowing unbound ACE2 to catalytically cleave Ang II to form Ang 1–7, and thus could decrease the likelihood of pulmonary edema during COVID-19 [14]. This evidence concerns the gene ACE2 and pulmonary edema.