CD274 and neoplasm: The European Medicines Agency (EMA) followed suit on September 21, 2018 however choosing to approve the drug for patients with PD-L1 expressing tumours (PD-L1 at least 1% on tumour cells assessed on archived pre-CRT tumour tissue using the VENTANA PD-L1 [SP263] immunohistochemistry assay) based on the results of an unplanned exploratory post-hoc analysis in a small patient subset, that failed to demonstrate an OS benefit in PD-L1 negative tumours.