AFP and hepatitis B virus infection: It should be of note that the study conducted by Chan SL [19] in Asian patients had higher sensitivity levels than that conducted by Biselli, et al. [20] Sensitivity of the AFP test in Asian countries, predominantly in developing countries such as in Indonesia, is believed to be higher because the prevalence of HCC with the etiology of hepatitis B tends to be higher—presumably due to the lower coverage of hepatitis B immunization in newborns [21].