An earlier study has reported that EGR2 was upregulated in the DNT cells of MRL-lpr (Faslpr mutation) and C3H-gld/gld (Faslgld mutation) lupus mice and bind to Fas ligand regulatory element (FLRE) to upregulate expression of Fas ligand (FasL) [21]. This evidence concerns the gene FAS and systemic lupus erythematosus.