CD4 and Autoimmunity: To determine the role of EGR2 specifically in T cells, Okamura et al. generated T cell specific EGR2 depletion B6 mice (CD4-CreEGR2−/−) and reported that EGR2 controls humoral immune responses and autoimmunity via regulating the function of TGFβ3-expressing CD4+CD25−LAG3+ Tregs [8].