To gain a better understanding of the function of elevated EGR2 in lupus, we think it is important and necessary in future studies to investigate EGR2 regulation in different immune cell subsets (such as CD4+ T cells, CD8+ T cells, B cells, Tregs, et al) directly in a lupus context by developing specific conditional EGR2 depletion murine lupus models. This evidence concerns the gene CD8A and systemic lupus erythematosus.