Looking into commonalities in upstream analysis between the NHBE and COVID-19 data, our data revealed 14 common activated (IFNL1, CST5, SPI1, TRAP1, IFNG, NUPR1, TGM2, SMARCB1, RNY3, STAT1, IRF9, PRL, IFNA2, and Interferon α) and 9 common suppressed (TAP1, GPER1, TFEB, UHRF2, ASPSCR1-TFE3, IL1RN, BTK, SYVN1, and MAPK1) networks. The gene discussed is CST5; the disease is COVID-19.