Indeed, among genetic causes of ALS are mutations of the valosin-containing protein (VCP), vesicle-associated membrane protein-associated protein B/C (VAPB), protein tyrosine phosphatase interacting protein 51 (PTPIP51), and the TAR DNA-binding protein 43 (TDP-43) [10,11]. This evidence concerns the gene VAPB and amyotrophic lateral sclerosis.