MAPT and frontotemporal dementia: Only one investigation stated that tau with pathogenic mutation P301L associated with frontotemporal dementia (FTD) had no impact on neurosteroid synthesis: neither the production of PROG nor allopregnanolone was modified in SH-SY5Y cells stably transfected by the mutant P301L tau and incubated with PREG as compared to native cells [44].