ACAT1 and type 1 diabetes mellitus: To address the issue, we examined here whether teneligliptin could inhibit ox-LDL uptake, foam cell formation, CD36 and ACAT-1 gene expression of macrophages isolated from streptozotocin-induced T1D mice and T1D patients as well as AGE-exposed mouse peritoneal macrophages and THP-1 cells.