Evaluation of CD47-SIRPα axis revealed: a) diffuse CD47 expression in the majority of cases both in the TC and the IF (Figure 6Aiii–iv and Figure S4A), and similarly to the expression of PD-L1, the levels of CD47 were lower in patients who received neoadjuvant therapy (Figure 6C and Figure S7A, p-value < 0.05); b) SIRPα was detected both in stromal and cancer cells in the majority of PDAC cases, independently of the neoadjuvant chemotherapy (Figure 6v,vi and Figure S4A). Here, CD274 is linked to cancer.