On March 2020, following the success of a multicentre, multiple cohort, open-label trial (NCT01658878), the FDA approved the use of ipilimumab in combination with nivolumab (OPDIVO, a anti PD-L1 drug) for patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib [94]. This evidence concerns the gene CD274 and hepatocellular carcinoma.