TNFRSF4 and neoplasm: Currently, a combination of MEDI6383, an OX40 ligand-Fc fusion protein, and anti-PD-L1 drug durvalumab is being investigated in patients with selected advanced stage solid tumour with the preclinical evidence that this combination has significantly expanded and increased the effector characteristics of mature T cells in the tumour-draining lymph nodes and tumour itself [236,237].