Therefore, ACE2 activity switches on the processing of Ang II in the classical RAS system and loss of ACE2 or its function could put the RAS system to an overall higher Ang II level [58].These cardioprotective activities of ACE2 are regulated through the Ang I (1–9)/AT2R and Ang I (1–7)/MasR axes [55].On the contrary, ACE degrades Ang (1–7) and forms ANG II that results in promoting inflammation, fibrosis, and high blood pressure (Figure 2). This evidence concerns the gene AGT and hypertensive disorder.