ACE2-led SARS-CoV-2 infection of alveolar pneumocytes (type II) cells has been suggested to trigger the onset of systemic inflammation and elevated immunoreactivity leading to a ‘cytokine storm’, that may essentially potentiate T-cell and macrophage activation infiltrating infected myocardial tissues and resulting in cardiac damage and myocarditis (Figure 1A). Here, ACE2 is linked to myocarditis.