These proteins included CLEC1B, CLM-6, epithelial discoidin domain-containing receptor 1 (DDR1), EZR, SKR3, tumour necrosis factor receptor superfamily member 21 (TNFRSF21), and PLXNB3 downregulated in AD, as well as interleukin 12 (IL12) and SPARC-related modular calcium-binding protein 2 (SMOC2) upregulated in AD. This evidence concerns the gene SMOC2 and Alzheimer disease.