For single proteins with FDR significance; TGF-α (AUC: 0.93, 95% CI: 0.82–1.00, p: 0.001) for plasma and CCL11 (AUC: 0.86, 95% CI: 0.73–1.00, p: 0.004) for EVs showed noteworthy results for diagnostics when comparing controls and patients with AD (Figure 4). Here, TGFA is linked to Alzheimer disease.